The relation between cigarette smoking and differential leukocyte count has not been well described. The present study was carried out to observe the changes in total and differential count of white blood cells of clinically healthy smokers in Ozamiz City, Philippines. Simple random sampling was used in selecting the healthy 30 smokers (15 male, 15 female) and 30 non-smokers (15 male, 15 female) from the target group. Standard blood collection procedure was utilized and blood samples were analyzed using SysmexXS-1000i. Results showed a significant increase in the total leukocyte count of smokers. Granulocytes and monocytes levels were significantly higher in smokers compared to the non-smokers. Among the granulocytes, there was a significant increase in eosinophil count in smokers, whereas the neutrophils were significantly lower. The lymphocyte and basophils were not significantly affected by smoking. The number of cigarettes smoked and number of days of smoking are positively correlated with the total leucocyte count. Cigarette smoking is associated with alterations in inflammatory markers among smokers.