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Journal of Multidisciplinary Studies

Discipline: Multidisciplinary Studies

The Journal of Multidisciplinary Studies (JMDS) is a peer-reviewed multidisciplinary journal which aims to publish biannually finest research articles in social sciences, natural sciences, engineering and technology and other subject areas. Submitted papers should describe original and previously unpublished works, not currently under review by another

JMDS provides a platform for dissemination of research findings, new research areas and techniques, conceptual developments and articles with practical applications and contribution to society.

Cytotoxic Long-chain Alkene and Terpene Isolated from the Methanol Extract of the Air-dried Leaves of Pipturus arborescens C.B. Rob
Charlie A. Lavilla, Jr., Mylene M. Uy, Shinji Ohta

A long-chain alkene (1-hexacosene) and a terpene were obtained from the bioactive methanol extract of the air-dried leaves of Pipturus arborescens (Link) C.B. Rob (“Handalamay”) collected from Poblacion, Kapatagan, Lanao del Norte. The compounds were isolated through extraction with ethanol, sequential partitioning with water-chloroform and hexane-90% methanol followed by fractionation and purification with repeated gravity column chromatography using gradient mixtures of hexane: ethyl acetate (1:1 ratio). The structures of the isolates were elucidated on the basis of spectroscopic data: 1H-and 13C-NMR, 1H-13C Heteronuclear Multiquantum Correlation (HMQC), 1H-13C Heteronuclear Multibond Correlation (HMBC), 1H-1H Homonuclear Correlation Spectroscopy (COSY), Infra-Red Spectroscopy (IR), Ultraviolet-Visible Spectroscopy (UV-VIS) and Mass Spectrometry (MS). The isolated compounds were shown to possess moderate cytotoxic activity against the brine shrimp Artemia salina (Leach).

KEYWORDS: bioactive, chromatography, fractionation, spectroscopy,1-hexacosene
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