Tuberculosis (TB) is a disease caused by infection with Mycobacterium tuberculosis that the government has remained in combat for some decades. The condition persisted even in the implementation of DOTS (Direct Observation Treatment Short-course) by the Department of Health. The detection of multidrug-resistant TB has hastened the menace of the scourge. Thus, this study evaluated DOTS program through treatment outcome for the period 2012-2015 in Ozamiz City, Philippines, using the descriptive method through documentary analysis. Records of TB-DOTS patients were obtained from the City Health Office. Collated data included age, sex, duration of treatment, the reason(s) to stop the procedure, and recurrence. A total of 1672 cases of TB treated with DOTS comprised the population of the study with 1065 males and 607 females. These registrants were categorized as pulmonary positive and pulmonary negative tuberculosis. The overall successful treatments for the specified period were 93.9% and 6.1 % for the treatment failure. This result is within the target rate of the World Health Organization which manifested the impact of TB-DOTS program in the area. Reasons for failure can be speculated to include poor patient observation during treatment, poor treatment compliance, inadequate recording and reporting system, inadequate treatment regimens, and an increased incidence of drug resistance. The result of the study can be used by the city health workers to revisit TB-DOTS program and formulate new policies to achieve 100% successful treatment.