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Brine Shrimp Lethality of Sinaw-Sinaw Peperomia pellucida (Linn.) Extracts

Fraulein Marie A. Bibanco, April Rose R. Talaba, Magdalene Mae DS. Palacio

Peperomia pellucida (Linn.) of Family Piperaceae, locally known as 'sinaw-sinaw', is an annual herb that is found in tropical countries. The plant has various histories of ethno-medicinal uses depending on the region. An assessment on the toxicity of this plant extract is essential to support therapeutical claims. This study was conducted to test for in vivo Brine Shrimp Lethality Assay (BSLA) of the crude aqueous and ethanolic extracts of Peperomia pellucida. Cytotoxicity was evaluated in terms of LC50 (lethality concentration). Ten nauplii were added into three replicates of each concentration of the plant extract. After 6, 12, and 24 hours of incubation, the surviving brine shrimp larvae were counted and LC50 was determined. Results showed that the P. pellucida crude aqueous and ethanolic extracts displayed mild cytotoxicity against brine shrimp nauplii with LC50 values of 46.55 ?g/mL and 74.13 ?g/mL, respectively. The findings of this present study may serve as a preliminary screen for further phytochemical studies and isolation of active compounds that can possibly be used for developing new drugs of therapeutic importance.

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